A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

The FDA has granted orphan drug designation (ODD) to LP-284, a next-generation acylfulvene small molecule, for the treatment ...

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

Zhi “Zack” Zheng is a member of molecular biologist Scott Keeney's lab. Zhi “Zack” Zheng, who is scheduled to receive his PhD from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences ...

Cars patched up after a wreck may look fixed—but never run quite as before. The same may hold true for chromatin, according to a study published in Science on November 6. In response to double-strand ...

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

New study shows that in women with BRCA1 or BRCA2 mutations, their breast cells already carry a clear pattern of DNA “damage ...

Broken String Biosciences launched an early access program (EAP) through which select developers of gene edited therapeutics will be able to use Broken String’s INDUCE-seq ® technology in their own ...