Molecular docking studies represent a cornerstone in modern drug discovery by providing detailed insights into the specific interactions between bioactive compounds and target enzymes. This ...

Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared using ...

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have ...

Recent evidence suggests that natural products are much more than simply agents of “microbial warfare” and actually play critical roles in bacterial pathogenesis and communication. In particular, ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

The development of new therapeutics targeting protein kinases is crucial in the fight against diseases like cancer.

Regulation of Oct4 signaling on tumorigenesis and modulation of wnt/β-catenin and TGF-β signal pathways in hepatocellular carcinoma cells. Efficacy of vemurafenib (V), a selective V600Eb-raf inhibitor ...

An international study led by scientists at Flinders University and at South China University of Technology has uncovered a new vulnerability in prostate cancer cells that could help improve treatment ...

Cardiovascular illnesses, such as high blood pressure and heart problems, are often treated with angiotensin-converting enzyme (ACE) inhibitors. The ACE inhibitors lower blood pressure by relaxing ...

Scientists have long assumed that once the smooth cartilage in a damaged knee wears away, the body has little chance of ...