The enzyme transhydrogenase plays a central role in regulating metabolic processes in animals and humans alike. Malfunction can lead to serious disorders. For the first time, structural biologists ...

Researchers have used cryo- electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes. This enzyme builds complex sugar trees ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

SANTA CRUZ, CA -- Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction ...

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond ...

A structural model of the telomerase enzyme shows how the binding domain (purple) tethers one end of the RNA component of the enzyme. (Image credit: Jansson et al., ) Researchers at UC Santa Cruz have ...

Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely used to treat a range of infections, including pneumonia and skin ...

Chemical structure for thiamine pyrophosphate and protein structure of transketolase. Thiamine pyrophosphate cofactor in yellow and xylulose 5-phosphate substrate in black. Credit: Thomas ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists have investigated a multi-enzyme complex that plays an essential role in metabolism ...

David Cantu and Tin Nguyen have received a 3-year, $599,999 grant from the National Science Foundation’s Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Program to support the creation ...