Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial. In ...

Scientists have uncovered a powerful genetic switch that helps some of the body’s most important immune cells grow up properly and keep our organs healthy. The switch, called MafB, guides immature ...

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that ...

Musculoskeletal disorders are a primary cause of disability worldwide, especially in aging societies like Japan. As individuals age, reductions in muscle mass and physical activity weaken the body's ...

An enzyme that controls the maturation and long-term survival of immune cells called macrophages has been discovered, with implications for research on aging and inflammatory disease. Virtually all ...

Recently these monocyte-derived alveolar macrophages, or Mo-AMs, were identified as key drivers of lung fibrosis disease progression. However, the mechanisms of their pro-fibrotic behavior and ...

Researchers at the University of Liège have identified a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs. The MafB factor, a veritable ...

Mrep accumulates in damaged muscle tissue and promotes muscle regeneration by acting on muscle satellite cells through activin A. While Mrep performs beneficial functions in normal muscle repair, in ...

This review centers on the maternal–fetal interface and focuses on the role of macrophages throughout the course of pregnancy. First, pregnancy is presented as a finely balanced immunological process: ...

The white blood cells' typical role is to promote inflammation and stimulate the immune response, but researchers say some actually appear to temper inflammatory conditions and improve healing.