Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Nucleic acid synthesis underpins life’s vital processes, from replication and transcription to the regulation of gene expression, while polymerase enzymology explores the molecular mechanisms by which ...

Since the discovery of the double-helical structure of DNA and postulation of the central dogma of molecular biology, stating that the flow of genetic information goes from DNA to RNA to protein, the ...

Our research focuses on all aspects of nucleic acid structure, chemistry and function employing state of the art technologies and approaches. The structure and chemistry of nucleic acids is ...

DNA, the blueprint of life, is best known for its fundamental role as genetic material—storing and transmitting biological information through the precise sequence of its bases. For decades, this ...

Thioguanosine (shown as S in the sequence) is placed at nearby, non-complementary positions within a DNA duplex. When exposed to light or mild oxidants, the modified bases react to form a disulfide ...

Extracellular vesicles (EVs) are tiny biological bubbles that carry nucleic acids and proteins between cells, playing an ...