Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

A new hypothesis article was published in Oncotarget (Volume 17) on January 3, 2026, titled “Hypothesis: HPV E6 and COVID ...

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...

In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...

Toxicologists have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes. The gene coding for the ...

GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.

The p53 protein plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long dubbed the protein p53 as the “guardian of the genome,” ...