Prostate cancer becomes fatal when associated with metastasis. In the October 10 Nature, Sooryanarayana Varambally and colleagues describe a microarray-based analysis of genes whose expression is ...

Changes in histone modifications of genes involved in flowering. (a) The removal of Polycomb complexes by SDG7 protein. (b) Transcription elongation and the deposition of H3K36me3 by SDG8 protein. PRE ...

Most of our genome is often written off as “junk DNA”, meaning it doesn’t encode for genes that get made into proteins. This so-called junk consists of accumulated DNA elements like viral DNA that got ...

Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptionally repressive chromatin modification but the mechanism of repression remains unclear. We devised and implemented a ...

Example of a tumour obtained by reducing the expression levels of a Polycomb protein. On the left is an example of precursor tissue of the eye during normal development. On the right, a tumour has ...

The roots of cancer run deep. Indeed, they’re usually assumed to run all the way to the blighted bits of DNA we call oncogenic mutations. But what if they don’t have to run quite that deep? What if ...