To stay healthy, our cells rely on a self-cleaning mechanism that removes defective or unnecessary components. This process, ...

Researchers identify two key proteins that allow chandelier cells to connect with excitatory neurons. This "handshake" regulates brain signals and, when disrupted, may lead to epilepsy or autism.

A selective protein degradation system known as Golgi membrane-associated degradation (GOMED), which identifies and removes ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein ...

Avenue Biosciences technology collects data sets on how specific signal peptides impact specific protein targets.

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...

Gastric cancer cells can activate KRAS-driven signals, enabling autonomous tumor growth by producing their own WNT proteins. New research reveals how gastric cancer cells exploit WNT signaling for ...

Inside the race to turn one of cell biology’s least understood processes into a new foundation for drug development and ...

Researchers have identified a single protein whose absence can cripple tumors in mice, slowing their growth and in some cases ...

Studying the activity of brain cells has never been straightforward. The central nervous system is incredibly complex, and unraveling the dense mesh of bioelectrical signaling inside is like trying to ...