Scientists reveal splicing-based mechanism driving therapy resistance in pediatric acute myeloid leukemia

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have ...
EurekAlert!

NUS and A*STAR researchers discover cell-type-specific link between alternative splicing and autoimmune disease inheritance

Computational biologists from the National University of Singapore (NUS) have uncovered how RNA splicing – a crucial process for isoform expression and protein diversity - is regulated across ...
Fred Hutch

RNA “typos” can highlight leukemia cells for immune attack

Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...
Science Daily

Biologists discover a new type of control over RNA splicing

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...
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Dual genetic mutations drive RNA mis-splicing and leukemia progression

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations – IDH2 and SRSF2 – work cooperatively to mis-splice RNA messages ...