Researchers have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study could inform ...

Video depiction of vesicle fusion and tethering. In the active zone in the central left of the video, docked vesicles (dark blue) fuse with the membrane, releasing their contents and being quickly ...

Researchers identify the Munc13-1 protein as a crucial molecular pathway for working memory, linking calcium signaling to synaptic strengthening.

α-synuclein (α-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphorylation of α-syn at ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining ...

Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a tiny fraction ...

Max Delbrück Center for Molecular Medicine in the Helmholtz Association Researchers led by Uljana Kravčenko and her colleagues in the lab of Professor Misha Kudryashev, Group Leader of the In Situ ...