Caspases are proteases that are best known for triggering apoptotic cell death. However, a study in Nature shows a novel, non-apoptotic role for caspases in the activation of microglia and subsequent ...

Caspases are proteases: enzymes that catalyze the breakdown of proteins and are part of the cysteine–aspartic acid protease family. They are vital to the mechanism of programmed cell death in animals ...

Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study The following ...

Here’s what you’ll learn when you read this story: When cells are about to die, they send signals that trigger proteins which are supposed to destroy them, but it doesn’t always happen that way. Some ...

When an individual suffers from cancer, the process of programmed cell death called apoptosis does not occur normally, permitting abnormal cells to thrive. When an individual suffers from cancer, the ...

The Xiao lab uses structural and chemical biology approaches to study the inflammasome signaling pathways, with the goal of targeting diverse diseases such as sepsis, multiple sclerosis, and AIDS ...