The human genome is about two meters long, yet it fits inside a nucleus only ~10 micrometers in diameter. A research team led ...

Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" ...

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" ...

DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a ...

Cancer drugs known as BET inhibitors once looked like a breakthrough, but in real patients they’ve often fallen short. New ...

A new software package called CREsted, published in Nature Methods, gives researchers an end-to-end workflow for modeling and ...

Previously, linker histone H1 was thought to bind stably to nucleosomes and compact chromatin by forming an ordered, “rigid” ...

This is where KMT2D comes in. Scientists have discovered that this enzyme facilitates the androgen receptor’s access to key ...

Within the realm of genetic regulation, chromatin modifications such as histone methylation and acetylation play pivotal roles in the transcriptional control of genes. Disruptions in these processes ...

As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA.

This study provides valuable insights into the role of MATR3 in oocyte maturation and folliculogenesis, using conditional knockout mice and in vitro follicle culture systems to show that MATR3 is ...