The accelerated cellular aging and altered gene activity in early-onset colorectal cancer, when not caused by inherited ...

Scientists have identified a little-known receptor, GPR133, as a powerful regulator of bone strength. By activating it with a newly discovered compound called AP503, they were able to boost bone ...

Opioids such as morphine, oxycodone and fentanyl provide pain relief by binding to mu-opioid receptors, which are specialized ...

Do dragonflies see like humans? Researchers discovered dragonflies use a red-sensing opsin identical to mammals. This study ...

There is growing demand for treatments that can safely prevent and reverse bone loss over time. Osteoporosis, a condition that weakens bones and makes ...

BACKGROUND: Despite antiplatelet therapy, some patients remain at high ischemic risk because of drug nonresponsiveness or high residual platelet reactivity). We aimed to target an orphan platelet GPCR ...

An international team, including scientists from Leipzig University, has gained important new insights into the regulation of ...

An international team, including scientists from Leipzig University, has gained important new insights into the regulation of food intake in mammals. The study, recently published in the renowned ...

Researchers found that intestinal tuft cells signal to crypt enterochromaffin cells by releasing acetylcholine, triggering serotonin release and activating a gut-to-brain vagal pathway during type 2 ...

We explore what allosteric modulators are, their benefits and drawbacks, and which candidates are currently advancing through ...

Performance driven by core drug discovery, continued adoption in environmental toxicology, and launch of new assays and ...

Peptide science has expanded rapidly in recent decades, revealing molecules with intriguing signaling roles that may influence diverse regenerative and organizational processes within an organism.