Scientists have identified a little-known receptor, GPR133, as a powerful regulator of bone strength. By activating it with a newly discovered compound called AP503, they were able to boost bone ...

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has revealed how a tryptophan-rich allosteric communication network regulates ...

BACKGROUND: Despite antiplatelet therapy, some patients remain at high ischemic risk because of drug nonresponsiveness or high residual platelet reactivity). We aimed to target an orphan platelet GPCR ...

Researchers found that intestinal tuft cells signal to crypt enterochromaffin cells by releasing acetylcholine, triggering serotonin release and activating a gut-to-brain vagal pathway during type 2 ...

The accelerated cellular aging and altered gene activity in early-onset colorectal cancer, when not caused by inherited ...

There is growing demand for treatments that can safely prevent and reverse bone loss over time. Osteoporosis, a condition that weakens bones and makes ...

Performance driven by core drug discovery, continued adoption in environmental toxicology, and launch of new assays and ...

A new review reveals how focal adhesion kinase (FAK) acts as a central regulator of tumor progression and immune suppression ...

We explore what allosteric modulators are, their benefits and drawbacks, and which candidates are currently advancing through ...

Peptide science has expanded rapidly in recent decades, revealing molecules with intriguing signaling roles that may influence diverse regenerative and organizational processes within an organism.

Placebo-adjusted mean weight loss of 16.3% (39 lbs) at 180 mg and 16.0% (37 lbs) at 240 mg at 44 weeks with no evidence of weight loss plateau in ...

What is the Cnpy1 protein? New research reveals how the Canopy1 protein allows vomeronasal neurons to survive high ER-stress.