Large-scale look at the exposome shows combined environmental exposures rival genetics in shaping human health outcomes

For decades, scientists have been carefully unraveling the role of genes in disease by examining how small variations in a person's genetic code can shape lifelong risk of developing common conditions ...

How an RNA-binding protein detects and responds to non-optimal codon usage in human cells

Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or ...
Ars Technica

OpenAI is acquiring open source Python tool-maker Astral

OpenAI announced Thursday that it has entered into an agreement to acquire Astral, the company behind popular open source Python development tools such as uv, Ruff, and ty, and integrate the company ...
AHA/ASA Journals

Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial

BACKGROUND: Premature atrial contractions (PACs) are independently associated with atrial fibrillation, stroke, and heart failure, yet no pharmacological therapy is approved for PAC suppression.
The Lancet

Association between GLP-1 receptor agonist use and worsening mental illness in people with depression and anxiety in Sweden: a national cohort study

For anxiety and depression that co-occur with diabetes and obesity, semaglutide and, to a lesser extent, liraglutide might be useful dually effective therapeutic options. Randomised controlled trials ...