Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine ...

Since launching her own lab at Yale in 2018, Candie Paulsen and her research team have been working to crack a longstanding mystery: How are pain signals regulated in the human body? And why do they ...

Since launching her own lab at Yale in 2018, Candie Paulsen and her research team have been working to crack a longstanding mystery: How are pain signals regulated in the human body? And why do they ...

Twenty years after she was convicted of killing her four children, Kathleen Folbigg has walked free. The pardon hinged on key scientific and medical evidence presented at an inquiry that began last ...

Using cryo-electron microscopy and mass spectrometry, researchers from PSI have deciphered the structure of an ion channel found in the eye while it interacts with the protein calmodulin – a structure ...

This useful study provides insights into mechanisms underlying oxidation regulation of Kv7 channels that contributes to regulating neuronal excitability. The experimental evidence in support of the ...

The neurotoxicity linked to pathogenesis may be generated by the cumulative effect by multiple biological insults. Therefore, the removal of only one of the insults may not affect the disease status ...

Calcium-calmodulin (CaM) signaling plays an essential role within and outside of the nervous system. Moreover, it is conserved from plants to humans. While a lot is known about the mechanisms of ...

A team of scientists has discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells. SidJ hijacks human protein ...

Angiogenesis, the process of building complex vascular structures, begins with sprout formation on preexisting blood vessels, followed by extension of the vessels through proliferation and migration ...

Probing biological networks with custom-shaped signaling inputs has long been a coveted dream of engineering-minded biologists, keenly aware of the power of analyzing man-made circuits with an ...