Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.

Fatty liver is an increasingly common disease that can progress toward more severe forms, involving inflammation, fibrosis, ...

A new sodium-ion cell for ESS may further improve competitiveness in large-scale systems against the weight of the ...

The firm is clinically testing the dual inhibitor in breast, prostate, colorectal, and lung cancer patients, as Pfizer is also exploring a similar dual-target strategy.

This study identifies the uncharacterised protein FAM53C as a novel, potential regulator of the G1/S cell cycle transition, linking its function to the DYRK1A kinase and the RB/p53 pathways. The work ...

Polysome profiling (a technique that separates cell contents to reveal which mRNAs are actively being made into proteins) revealed that in cells lacking Pfk2, mRNAs for critical cell cycle ...

Polysome profiling (a technique that separates cell contents to reveal which mRNAs are actively being made into proteins) revealed that in cells lacking Pfk2, mRNAs for critical cell cycle regulators ...

Five years ago, scientists watched in wonder as synthetic bacteria grew and split into daughter cells. The bacteria’s extremely stripped-down genome still supported its entire life cycle. It was a ...

Things are not easy for the alternative protein sector, and this is especially true for cultivated meat. Despite significant progress, a number of problems still loom large. One of the most ...

The team simulated a living cell at nanoscale resolution and recapitulated how every molecule within that cell behaved over the course of a full cell cycle. The work took many years: vast computer ...

A simulated cell in the early stages of division. Left half shows cytoplasm (blue cubes), mRNA degradation machinery molecules (pink), and sugar transporters (brown). Right half adds the membrane ...

The ubiquitin–proteasome system (UPS) is a central mechanism for maintaining cellular homeostasis through the regulated turnover of proteins (Pickart, 2001; Hershko and Ciechanover, 1998).