Scientists created a definitive E3 ligase atlas, resolving inconsistencies and enabling better disease research and drug design.

Intracellular transport is a vital process that allows cells to move proteins and other molecules to specific locations.

Fi Novelist Who Disappeared for Decades In “What We Are Seeking,” the cult author Cameron Reed returns to show us a strange, ...

LG Chem has doubled down on developing an innovative cancer treatment by zeroing in on undruggable targets through a ...

FMC-220, which as shown preclinical activity in solid tumors with TP53 loss-of-function mutations, is poised to enter clinical trials.

FMC-220 was discovered using the Frontier (TM) Platform, integrating chemoproteomics and AI for covalent-based drug discovery. FMC-220 is the second potential first-in-class program to advance from ...

Discover how TP53 mutations in adult leukaemia impact treatment outcomes and potential strategies for improved patient care.

Alzheimer’s disease, or AD, is a terrible illness that is currently affecting 7.2 million adults in the United States. The ...

The start-up Function will send practically anyone to a lab for extensive medical testing, no physical required. Is that a good thing? By Kristen V. Brown As Kimberly Crisp approached middle age, ...

The gene p53 acts as a tumor suppressor and is often called the guardian of the genome. This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading to ...

ABSTRACT: Endometrial cancer is a common malignant tumor among women in China, with 77,000 new cases and 13,500 deaths reported in 2022. Its incidence continues to rise alongside increased lifespan ...

Wistar Institute researchers have overturned three decades of scientific thinking about p53, the most important tumor suppressor protein in cancer research. In a study published in Molecular Cell, ...